Welcome to Allegheny College’s DSpace repository. Our institutional repository is rich with Allegheny history and important documents, including
- The Documents of Ida M. Tarbell, a digitized collection of papers from the groundbreaking journalist, author, and lecturer
- Civil War letters of Pvt. Willard A. Cutter and Stephen R. Clark
- The Campus student newspaper and The Kaldron student yearbooks.
- Senior Projects (currently available to Allegheny community only)
- Course Syllabi (currently available to Allegheny community only)
Portions of this repository are restricted to current Allegheny students, faculty, and staff. To ensure that you are seeing everything you have access to, please Log In with your Allegheny Username and Password.
Recent Submissions
Item 2024-09-27: The Campus(Allegheny College, 2024-09-27)Item 2024-09-20: The Campus(Allegheny College, 2024-09-20)Item 2024-09-13: The Campus(Allegheny College, 2024-09-13)Item 2024-09-06: The Campus(Allegheny College, 2024-09-06)Item Glucocorticoid Receptor Signaling Is Critical for Mouse Corneal Development, Inhibition of Inflammatory Response, and Neovascularization of the Cornea(Elsevier Inc. on behalf of the American Society for Investigative Pathology, 2024-09-23)The cornea protects the interior of the eye from external agents such as bacteria, viruses, and debris. Synthetic glucocorticoids are widely prescribed in the treatment of ocular infections and disorders. The actions of glucocorticoids are mediated by the glucocorticoid receptor (GR); however, the molecular and physiological functions of GR signaling in the cornea are poorly understood. This study found that treatment of mice with glucocorticoid eye drops led to a profound regulation of the corneal transcriptome. These glucocorticoid-regulated genes were associated with multiple biological functions, including the immune response. To understand the direct role of GR signaling in the cornea, mice with conditional knockout of GRs in the corneal epithelium were generated. Mice lacking corneal GRs exhibited microphthalmia, loss of pupils, a deformed and opaque lens, and mislocalization of key structural proteins within the corneal epithelial layers. Global transcriptomic approaches revealed that loss of GR signaling in the cornea also resulted in the dysregulation of a large cohort of genes strongly associated with an enhanced inflammatory response. Finally, corneal GR signaling was required for preventing neovascularization of blood and lymphatic vessels and thereby immune cell infiltration of the cornea. These results reveal that corneal GR signaling plays a critical role in ocular development and in maintaining the homeostasis of the eye.
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