Welcome to Allegheny College’s DSpace repository. Our institutional repository is rich with Allegheny history and important documents, including

Portions of this repository are restricted to current Allegheny students, faculty, and staff. To ensure that you are seeing everything you have access to, please Log In with your Allegheny Username and Password.

Recent Submissions

  • Item
    2024-09-27: The Campus
    (Allegheny College, 2024-09-27)
  • Item
    2024-09-20: The Campus
    (Allegheny College, 2024-09-20)
  • Item
    2024-09-13: The Campus
    (Allegheny College, 2024-09-13)
  • Item
    2024-09-06: The Campus
    (Allegheny College, 2024-09-06)
  • Item
    Glucocorticoid Receptor Signaling Is Critical for Mouse Corneal Development, Inhibition of Inflammatory Response, and Neovascularization of the Cornea
    (Elsevier Inc. on behalf of the American Society for Investigative Pathology, 2024-09-23) Kadmiel, Mahita; Diaz-Jimenez, David; Oakley, Robert H.; Petrillo, Maria G.; He, Bo; Xu, Xiaojiang; Cidlowski, John A.; Kadmiel, Mahita; Biology
    The cornea protects the interior of the eye from external agents such as bacteria, viruses, and debris. Synthetic glucocorticoids are widely prescribed in the treatment of ocular infections and disorders. The actions of glucocorticoids are mediated by the glucocorticoid receptor (GR); however, the molecular and physiological functions of GR signaling in the cornea are poorly understood. This study found that treatment of mice with glucocorticoid eye drops led to a profound regulation of the corneal transcriptome. These glucocorticoid-regulated genes were associated with multiple biological functions, including the immune response. To understand the direct role of GR signaling in the cornea, mice with conditional knockout of GRs in the corneal epithelium were generated. Mice lacking corneal GRs exhibited microphthalmia, loss of pupils, a deformed and opaque lens, and mislocalization of key structural proteins within the corneal epithelial layers. Global transcriptomic approaches revealed that loss of GR signaling in the cornea also resulted in the dysregulation of a large cohort of genes strongly associated with an enhanced inflammatory response. Finally, corneal GR signaling was required for preventing neovascularization of blood and lymphatic vessels and thereby immune cell infiltration of the cornea. These results reveal that corneal GR signaling plays a critical role in ocular development and in maintaining the homeostasis of the eye.

Communities in DSpace

Select a community to browse its collections.

Now showing 1 - 5 of 7
  • College Committees / Shared Governance
    College Meeting minutes and supporting documents including student government minutes
  • Institutional Effectiveness
    Documents associated with assessment and institutional research.
  • Merrick Archives
    Digital collections from archives holdings including: Allegheny’s First One Hundred Years; Borges at Allegheny College 1985; Reflections on the COVID-19 Pandemic; Reflections on Social (In) Justice
  • Special Collections
    The Documents of Ida M. Tarbell and Civil War Letters of Stephen R. Clark, Ohio Calvary and Willard Cutter, 150th Pennsylvania Regiment, Company K.
  • Student Publications
    Allegheny’s student newspaper The Campus and Kaldron (yearbook)