Optimization of the Microwave-Assisted Mannich Reaction: Developing a Laboratory Module for Use in Undergraduate Chemistry Courses
Persistent URL
Author(s)
De Graef, Erika
Date Issued
April 29, 2022
Abstract
With the ultimate goal of determining whether a stereoselective Mannich reaction is suitable for an undergraduate laboratory module, the proline-catalyzed Mannich reaction was adapted to microwave conditions in order to efficiently synthesize N-(4-methoxyphenyl)-4-oxonorvaline ethyl ester. Synthesis of the intermediate imine (Methyl 2-[(4-methoxyphenyl)imino]acetate) was achieved in high yield (95%+) and can be used without purification, however the Mannich reaction itself resulted in variable yields, low purity, and poor reproducibility.
Major
Chemistry
First Reader(s)
Betush, Matt
Other Reader(s)
Ams, Mark R.
Flanagan, Moira L.
Department
Chemistry
Type of Publication
Senior Project Paper
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Name
De Graef - Chemistry Senior Project - 4.29.22.pdf
Size
3.17 MB
Format
Adobe PDF
Checksum (MD5)
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