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dc.contributor.authorHumphreys, Tricia L.
dc.contributor.authorBedell, Hillary
dc.contributor.authorNawrocki, Erin
dc.date.accessioned2013-05-31T19:40:12Z
dc.date.available2013-05-31T19:40:12Z
dc.date.issued2013-05
dc.identifier.citationNawrocki, Erin M., Hillary W. Bedell, and Tricia L. Humphreys. "Resveratrol is cidal to both classes of Haemophilus ducreyi." International Journal of Antimicrobial Agents, 41, no. 5 (May 2013), 477-479.en_US
dc.identifier.issn0924-8579
dc.identifier.urihttp://hdl.handle.net/10456/34770
dc.description.abstractResveratrol, a polyphenolic phytoalexin, is produced by plants in response to infection and has antibacterial activity. Haemophilus ducreyi is a Gram-negative bacterium that is the causative agent of the sexually transmitted disease chancroid. This study employed minimum cidal concentration (MCC) assays to evaluate the potential of resveratrol as a microbicide against H. ducreyi. Five class I and four class II strains of H. ducreyi tested had MCCs ≤500 μg/mL. Resveratrol was also tested against Lactobacillus spp., part of the natural vaginal flora. Representative strains of Lactobacillus were co-cultured with H. ducreyi and 500 μg/mL resveratrol; in all cases, Lactobacillus was recovered in greater numbers than H. ducreyi. These results show that resveratrol is not only bacteriostatic but is bactericidal to H. ducreyi, confirming the compound's potential for use as a topical microbicide to prevent chancroid.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Antimicrobial Agentsen_us
dc.subjectHaemophilus ducreyien_US
dc.subjectChancroiden_US
dc.subjectLactobacillusen_US
dc.subjectResveratrolen_US
dc.subjectMicrobicideen_US
dc.titleResveratrol is cidal to both classes of Haemophilus ducreyien_US
dc.typeArticleen_US
dc.contributor.departmentBiologyen_US
dc.description.embargoNo embargoen_US
dc.citation.volume41en_US
dc.citation.issue5en_US
dc.citation.spage477en_US
dc.citation.epage479en_US
dc.identifier.doi10.1016/j.ijantimicag.2013.02.008en_US


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