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dc.contributor.authorFonner, Chris W.
dc.contributor.authorBoord, Shelby M.
dc.contributor.authorPatel, Shreya A.
dc.contributor.authorVenesky, Matthew D.
dc.contributor.authorWoodley, Sarah K.
dc.date.accessioned2017-04-17T13:05:25Z
dc.date.available2017-04-17T13:05:25Z
dc.date.issued2017-03-06
dc.identifier.citationFonner, C.W., Patel, S.A., Boord, S.M., Venesky, M.D., and Woodley, S.K. (2017). Effects of corticosterone on infection and disease in salamanders exposed to the amphibian fungal pathogen Batrachochytrium dendrobatidis. Diseases Of Aquatic Organisms 123(2): 159-171. DOI: 10.3354/dao03089en_US
dc.identifier.issn0177-5103
dc.identifier.issn1616-1580
dc.identifier.urihttp://hdl.handle.net/10456/42639
dc.description.abstractAlthough it is well established that glucocorticoid hormones (GCs) alter immune function and disease resistance in humans and laboratory animal models, fewer studies have linked elevated GCs to altered immune function and disease resistance in wild animals. The chytrid fungal pathogen Batrachochytrium dendrobatidis (Bd) infects amphibians and can cause the disease chytridiomycosis, which is responsible for worldwide amphibian declines. It is hypo thesized that long-term exposure to environmental stressors reduces host resistance to Bd by suppressing host immunity via stress-induced release of GCs such as corticosterone (CORT). We tested whether elevation of CORT would reduce resistance to Bd and chytridiomycosis development in the red-legged salamander Plethodon shermani. Plasma CORT was elevated daily in animals for 9 d, after which animals were inoculated with Bd and subsequently tested for infection loads and clinical signs of disease. On average, Bd-inoculated animals treated with CORT had higher infection abundance compared to Bd-inoculated animals not treated with CORT. However, salamanders that received CORT prior to Bd did not experience any increase in clinical signs of chytridiomycosis compared to salamanders not treated with CORT. The lack of congruence between CORT effects on infection abundance versus disease may be due to threshold effects. Nonetheless, our results show that elevation of plasma CORT prior to Bd inoculation decreases resistance to infection by Bd. More studies are needed to better understand the effects of CORT on animals exposed to Bd and whether CORT variation contributes to differential responses to Bd observed across amphibian species and populations.en_US
dc.description.sponsorshipDuquesne University Faculty Development Award; National Science Foundation; American Society for Biochemistry and Molecular Biology Undergraduate Research Award; Duquesne Undergraduate Summer Research Programen_US
dc.language.isoen_USen_US
dc.publisherInter-Researchen_US
dc.relation.ispartofDiseases Of Aquatic Organismsen_US
dc.relation.isversionofhttps://doi.org/10.3354/dao03089en_US
dc.rightsThis article is published and restricted to a 5 year embargo. Please use the DOI link provided for full access until March 6, 2022. Copyright remains with the original owner.en_US
dc.subjectBehavioren_US
dc.subjectChytridiomycosisen_US
dc.subjectDiseaseen_US
dc.subjectPlethodon Shermanien_US
dc.subjectGlucocorticoiden_US
dc.subjectStress hormoneen_US
dc.subjectImmunityen_US
dc.titleEffects of corticosterone on infection and disease in salamanders exposed to the amphibian fungal pathogen Batrachochytrium dendrobatidisen_US
dc.description.versionPublished articleen_US
dc.contributor.departmentBiologyen_US
dc.description.embargoThis version of the article is available for viewing to the public after March 6, 2022.en_US
dc.citation.volume123en_US
dc.citation.issue2en_US
dc.citation.spage159en_US
dc.citation.epage171en_US
dc.identifier.doi10.3354/dao03089
dc.contributor.avlauthorVenesky, Matthew D.


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