ACUTE DEEP BRAIN STIMULATION: AN INVESTIGATION OF THE NUCLEUS ACCUMBENS AND THE LATERAL HABENULA INHIBITORY EFFECTS ON COCAINE REINFORCEMENT USING MEASURES OF CONDITIONED PLACE PREFERENCE
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First ReaderHollerman, Jeffrey
Additional ReadersCross, Jeffrey
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Subjectaddiction; deep brain stimulation; nucleus accumbens; lateral habenula; conditioned place preference
Project AbstractDeep brain stimulation (DBS) is a non-pharmacological intervention that has been investigated as a treatment for depression, OCD, Parkinson’s disease and addiction. Several areas in the mesolimbic dopaminergic system have been considered potential targets for stimulation. The goal of this study is to compare the effectiveness of DBS in the lateral habenula and the nucleus accumbens to compare their effects on reward-seeking behavior. 15 Sprague-Dawley rats were divided into 3 groups. The NAc and the LHb groups received surgery resulting in an implanted electrode, the control group received a sham electrode surgery. All three groups were conditioned to associate a particular scent with the cocaine-paired chamber of the conditioned place preference apparatus. After a conditioning phase, the animals received one day of acute DBS in the cocaine-paired chamber. The two consecutive days following DBS the animals went through post-conditioning trials to examine how the amount of time spent in their preferred chamber changed. The data showed that although there was not a significant effect in the time spent in the preferred chamber between groups, there was significance found between the times they spent in the chambers and the trail days. This indicates that a conditioning effect took place, and that following the stimulation, extinction took place. This study indicates the effectiveness of condition place preference as a way to test an animal model of addiction. In future research, the information from this experiment can be used to explore the effectiveness of altering the frequencies of stimulation used in DBS.