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dc.contributor.authorMöller, Clara M.
dc.contributor.authorOlsa, Eamon J.A.
dc.contributor.authorGinty, Annie T.
dc.contributor.authorRapelje, Alyssa L.
dc.contributor.authorTindall, Christina L.
dc.contributor.authorHolesh, Laura A.
dc.contributor.authorPetersen, Karen L.
dc.contributor.authorConklin, Sarah M.
dc.date.accessioned2017-12-13T18:00:45Z
dc.date.available2017-12-13T18:00:45Z
dc.date.issued2017-10-01
dc.identifier.citationMöller, C.M., Olsa, E.J.A, Ginty, A.T., Rapelje, A.L., Tindall, C.L., Holesh, L.A., Petersen, K.L., Conklin, S.M. (2017). Influence of Acute Multispecies and Multistrain Probiotic Supplementation on Cardiovascular Function and Reactivity to Psychological Stress in Young Adults: A Double-Blind, Randomized, Placebo-Controlled Trial. Psychosomatic Medicine 79(8): 914-919. doi:10.1097/PSY.0000000000000489en_US
dc.identifier.issn0033-3174
dc.identifier.urihttp://hdl.handle.net/10456/45375
dc.descriptionReceived for publication April 15, 2016; revision received May 1, 2017.en_US
dc.description.abstractObjective The potential influence of probiotic supplementation on cardiovascular health and stress responsivity remains largely unexplored. Some evidence suggests the possibility that probiotics may influence blood pressure. A separate body of research suggests that exaggerated cardiovascular reactions to acute psychological stress in the laboratory predict cardiovascular morbidity and mortality. The current investigation explored the effect of acute probiotic use on (1) resting cardiovascular measures in healthy young adults and (2) cardiovascular and psychological reactions to an acute psychological stressor in the laboratory. Method Participants (N = 105, M [SD] age = 20.17 [1.26], 84.8% white) completed a 2-week, double-blind, and placebo-controlled trial of a multispecies and multistrain probiotic. Exclusion criteria included previous probiotic use, diagnosed gastrointestinal disorder, and/or current antibiotic use. At visits 1 and 2, participants completed the Paced Auditory Serial Addition Test, a widely used psychological stress task. Participants were randomly assigned to a probiotic blend or matched placebo. Results Compared with placebo, 2-week probiotic supplementation did not affect resting measures of cardiovascular function, cardiovascular responses during or recovery from stress, or psychological reactions to acute psychological stress. Conclusions Contrary to expectations, short-term use of a probiotic supplement in healthy participants did not influence measures of cardiovascular function or responsivity to psychological stress. Future research is needed to determine species- and strain-specific effects of probiotics in healthy participants with various degrees of stress responsiveness, as well as in diseased populations.en_US
dc.language.isoen_USen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofPsychosomatic Medicineen_US
dc.relation.isversionofhttps://doi.org/10.1097/PSY.0000000000000489en_US
dc.rightsPost-print may be deposited in personal website or institutional repository Publisher's version/PDF cannot be used Must include statement that it is not the final published version Published source must be acknowledged with full citationen_US
dc.subjectacute probiotic interventionen_US
dc.subjectacute psychological stressen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectCardiovascular healthen_US
dc.subjectCardiovascular reactivityen_US
dc.titleInfluence of Acute Multispecies and Multistrain Probiotic Supplementation on Cardiovascular Function and Reactivity to Psychological Stress in Young Adults: A Double-Blind, Randomized, Placebo-Controlled Trialen_US
dc.description.versionPublished articleen_US
dc.contributor.departmentNeuroscienceen_US
dc.contributor.departmentPsychologyen_US
dc.citation.volume79en_US
dc.citation.issue8en_US
dc.citation.spage914en_US
dc.citation.epage919en_US
dc.identifier.doi10.1097/PSY.0000000000000489
dc.contributor.avlauthorConklin, Sarah M.


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