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dc.contributor.authorThu, Yee Mon
dc.date.accessioned2022-11-22T18:39:02Z
dc.date.available2022-11-22T18:39:02Z
dc.date.issued2020-10
dc.identifier.citationYee Mon Thu, How Not To Be in the Wrong Place at the Wrong Time: An Education Primer for Use with “Deposition of Centromeric Histone H3 Variant CENP-A/Cse4 into Chromatin Is Facilitated by Its C-Terminal Sumoylation”, Genetics, Volume 216, Issue 2, 1 October 2020, Pages 333–342, https://doi.org/10.1534/genetics.120.303493en_US
dc.identifier.issn0016-6731
dc.identifier.issn1943-2631
dc.identifier.urihttps://dspace.allegheny.edu/handle/10456/55920
dc.description.abstractRecent work by Kentaro Ohkuni and colleagues exemplifies how a series of molecular mechanisms contribute to a cellular outcome-equal distribution of chromosomes. Failure to maintain structural and numerical integrity of chromosomes is one contributing factor in genetic diseases such as cancer. Specifically, the authors investigated molecular events surrounding centromeric histone H3 variantdeposition-a process important for chromosome segregation, usingSaccharomyces cerevisiaeas a model organism. This study illustrates an example of a post-translational modification-sumoylation-regulating a cellular process and the concept of genetic interactions (e.g., synthetic dosage lethality). Furthermore, the study highlights the importance of using diverse experimental approaches in answering a few key research questions. The authors used molecular biology techniques (e.g., qPCR), biochemical experiments (e.g., Ni-NTA/8His protein purification), as well as genetic approaches to understand the regulation of. At a big-picture level, the study reveals how genetic changes can lead to subsequent molecular and cellular changes.en_US
dc.language.isoen_USen_US
dc.publisherGenetics Society Americaen_US
dc.relation.ispartofGeneticsen_US
dc.relation.isversionofhttp://dx.doi.org/10.1534/genetics.120.303493en_US
dc.rightsCopyright © 2020 by the Genetics Society of Americaen_US
dc.subjectPrimer articleen_US
dc.subjectCentromeric histone H3 varianten_US
dc.subjectCse4en_US
dc.subjectPost-translational modificationen_US
dc.subjectSumoylationen_US
dc.titleHow Not To Be in the Wrong Place at the Wrong Time: An Education Primer for Use with Deposition of Centromeric Histone H3 Variant CENP-A/Cse4 into Chromatin Is Facilitated by Its C-Terminal Sumoylationen_US
dc.description.versionPublished articleen_US
dc.contributor.departmentBiochemistryen_US
dc.contributor.departmentBiologyen_US
dc.citation.volume216en_US
dc.citation.issue2en_US
dc.citation.spage333en_US
dc.citation.epage342en_US
dc.identifier.doi10.1534/genetics.120.303493
dc.contributor.avlauthorThu, Yee Mon


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