Resveratrol is cidal to both classes of Haemophilus ducreyi
Persistent URL
Author(s)
Humphreys, Tricia L.
Bedell, Hillary
Nawrocki, Erin
Date Issued
May 2013
Abstract
Resveratrol, a polyphenolic phytoalexin, is produced by plants in response to infection and has antibacterial activity. Haemophilus ducreyi is a Gram-negative bacterium that is the causative agent of the sexually transmitted disease chancroid. This study employed minimum cidal concentration (MCC) assays to evaluate the potential of resveratrol as a microbicide against H. ducreyi. Five class I and four class II strains of H. ducreyi tested had MCCs ≤500 μg/mL. Resveratrol was also tested against Lactobacillus spp., part of the natural vaginal flora. Representative strains of Lactobacillus were co-cultured with H. ducreyi and 500 μg/mL resveratrol; in all cases, Lactobacillus was recovered in greater numbers than H. ducreyi. These results show that resveratrol is not only bacteriostatic but is bactericidal to H. ducreyi, confirming the compound's potential for use as a topical microbicide to prevent chancroid.
Journal
International Journal of Antimicrobial Agents
Department
Biology
Citation
Nawrocki, Erin M., Hillary W. Bedell, and Tricia L. Humphreys. "Resveratrol is cidal to both classes of Haemophilus ducreyi." International Journal of Antimicrobial Agents, 41, no. 5 (May 2013), 477-479.
Publisher
Elsevier
Embargo
No embargo
DOI
10.1016/j.ijantimicag.2013.02.008
ISSN
0924-8579
Type of Publication
Article
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Humphreys Nawrocki Bedell.pdf
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