Chalcogen Bonding “2S–2N Squares” versus Competing Interactions: Exploring the Recognition Properties of Sulfur
Persistent URL
Author(s)
Ams, Mark R.
Trapp, Nils
Schwab, Anatol
Milić, Jovana V.
Diederich, François
Date Issued
December 11, 2018
Abstract
"
Chalcogen bonding (CB) is the focus of increased attention for its applications in medicinal chemistry, materials science, and crystal engineering. However, the origin of sulfur's recognition properties remains controversial, and experimental evidence for supporting theories is still emerging. Here, a comprehensive evaluation of sulfur CB interactions is presented by investigating 2,1,3‐benzothiadiazole X‐ray crystallographic structures gathered from the Cambridge Structure Database (CSD), Protein Data Bank (PDB), and own laboratory findings. Through the systematic analysis of substituent effects on a subset library of over thirty benzothiadiazole derivatives, the competing interactions have been categorized into four main classes, namely 2S–2N CB square, halogen bonding (XB), S⋅⋅⋅S, and hydrogen‐bonding (HB). A geometric model is employed to characterize the 2S–2N CB square motifs and discuss the role of electrostatic, dipole, and orbital contributions toward the interaction."
Journal
Chemistry - A European Journal
Department
Chemistry
Citation
Ams, M. R., Trapp, N., Schwab, A., Milić, J. V., & Diederich, F. (2019). Chalcogen bonding “2S–2N squares” versus competing interactions: Exploring the recognition properties of sulfur. Chemistry – A European Journal, 25(1), 323-333. doi:10.1002/chem.201804261
Publisher
Wiley
Version of Article
Published article
Embargo
This version of the article is available for viewing to the public after December 11, 2019
DOI
10.1002/chem.201804261
ISSN
0947-6539
1521-3765
Rights
This is the peer reviewed version of the following article: Ams, M. R., Trapp, N., Schwab, A., Milić, J. V., & Diederich, F. (2019). Chalcogen bonding “2S–2N squares” versus competing interactions: Exploring the recognition properties of sulfur. Chemistry – A European Journal, 25(1), 323-333. doi:10.1002/chem.201804261, which has been published in final form at https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201804261. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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