The Investigation of Hollow Gold Nanoparticles as a Targeted Drug Delivery System
Persistent URL
Author(s)
Rios, Antonio
Date Issued
April 11, 2025
Abstract
Silver nanoparticles were synthesized using sodium borohydride and employed in a galvanic replacement reaction to produce hollow gold nanoparticles. The resulting hollow gold nanoparticles exhibited a resonance peak at 976nm, consistent with their hollow morphology and localized surface plasmon resonance properties. These characteristics make them promising candidates for drug delivery systems and targeted cancer therapies. To simulate drug loading, Methyl Orange and Acid Orange 5 were used as dye analogs for small-molecule drugs. This study confirms the feasibility of dye loading into Tween 20-stabilized hollow gold nanoparticles. Langmuir Isotherm modeling was used to evaluate loading behavior, yielding a maximum loading capacity of 62.19 and an equilibrium constant of 0.016 for Acid Orange 5, while Methyl Orange exhibited a maximum loading capacity of 56.67 and an equilibrium constant of 0.019. The Langmuir model fit well for Acid Orange 5 but not for Methyl Orange, which was linear at low concentrations, suggesting behavior more indicative of a very high K value and a system approaching saturation rapidly. These results demonstrate how dye structure and surface functionalization influence loading efficiency and binding behavior, offering insight into the optimization of nanoparticle-based drug delivery systems.
Major
Biochemistry
First Reader(s)
Deckert, Alice A.
Other Reader(s)
Nelson, Margaret K.
Guldan, Beth
Department
Biochemistry
Type of Publication
Senior Project Paper
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Name
Antonio Rios Comp Final.pdf
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492.87 KB
Format
Adobe PDF
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